I got given this tip about a year ago and my friend called it 'The Oprah Effect'
All you have to do is look through Oprahs website, find out what she is going to be talking about on her upcoming shows or what she has been talking about recently. Find good promotions that fit into what she is talking about. Set up your campaigns, PPC is best but articles work.
Usually she talks about specific products (no doubt getting her own cut, perhaps Oprah is the world #1 affiliate) like last this year it was all those weight loss teas. The searches increase dramatically whenever she talks about something, its insane.
No kidding, listen to Oprah, she can make you rich!!!