I've emailed a publisher of a list I'm subscribed to before and he has always been kind enough to answer my questions. I know he has a rather large subscriber base, but he has on several occasions taken the time to reply back to my questions. I ended up making a purchase through his affiliate link because of him answering my questions.
Just for him taking the time to write a quick reply he is now getting reoccurring monthly income from the tool subscription I had bought through his link. I might have still bought the tool without his input, but since he took the time to help I used his link.
I know for some it would almost be impossible to reply to all your emails. However taking to time to do so may go a long way in building up your relationships with your subscribers and also your income.