A good way to respond to that is with a question. A phrase I love in this case is, "If you don't mind me asking ..."
For example. Let's say I'm approaching a business with videos designed to promote their business to new customers. What I like to do is frame my question in a way that can potentially identify a need.
Here's how that might unfold. He says, "I'm not interested" So I might say, "If you don't mind me asking, are you in the middle of any kind of marketing campaign right now, for example - are you doing anything online?"
9 times out of 10 he's not going to answer this question with another "I'm not interested". Instead, you're going to be able to start a conversation about what he's currently doing. Because typically he'll tell you what he's doing, how it's working, how he feels about marketing, etc. Now we're getting somewhere! because this is all valuable information for helping me know what to present and how to lead the conversation the direction I want it to go.
Follow up questions to the above could be: If they ARE in a campaign;
"Really? How's that working out so far? Are you happy with the return you're getting?" (Hint: usually they're not) "Have you ever tried any kind of video marketing before?" [Now we're talking! That last question is the beginning of the conversation I wanted to have in the first place!]
Of course you're not just peppering him with questions. The example I just gave assumes there's been interaction between questions.
If he says he's not in a campaign at the moment I might ask,
"Really? Just curious - besides word of mouth what's been the most reliable form of advertising for you in the past?"
Next question - "Have you ever tried any kind of video marketing?" (Bingo!)
"The reason I asked is because in 2014 people will pay more attention to video than any other form of advertising because ... etc., etc., etc" and away you go with your reasoning, facts, examples, etc.!
"What that means to you is ...." now it's time to talk BENEFITS!
Notice what's happening? Now you're in a presentation and you've neutralized the "Not interested" objection!
What are some of the ways other warriors selling to offliners answer the "Not Interested" objection?