It depends;

If you are looking to develop a website from scratch, then doing it in WordPress would be the best option. It's easy and you will find it pretty resourcefull (for yourself and for your visitors).

In case you are looking to buy any pre-made script; then I would suggest you to buy it in WordPress CMS, as it will be easy for you to manage and to maintain your site with changing trends.

Good luck.

another PHP things aside of wordpress? it seems WP is very popular with this.