Yes.. it will in some occasion,
just like :
the clicked visitor come from search engine
the relevancy of your content

You can Increase Adsense CPC by following method:
1) Concentrate on Keywords, niche and topic
2) Enable Image and Text Ads.
3) Too many Ads – Less CPC
4) Monitor your Higher CTR Ad with Custom Channels
5) First Ad unit in HTML Code Serves better ads
6) Reduce Accident, Fraud and Useless Clicks

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Focused on keyword research and content according to niches and try to get traffic from the search engine.it will give you better results.