Personas and Segmentation in Google Analytics

Hello all, I'm looking for a bit of advice and hoping some of you can guide me. I have a client that has 4 different personas that they are chasing. I would like to make these more specific segments within google analytics so they are not catching every person fitting age/sex/location but not so specific I am missing visitors.

For instance one partial persona is:
Jodie: 45-year-old middle class woman from Bridgeman Downs. No kids, in a long-term relationship, educated, working in the care industry, has ongoing issues with stress triggering anxiety and depression. (ie: 90k-150k income, Health care professional/industry, 2 years + university education, No kids, Travels and shops but on a budget).

Now I can segment on Age, sex and Location. How can I try to incorporate some of values like in the description above within the targeting abilities of google analytics, ie Affinity Category, In-market Segment and/or Other Category?

How far would you recommend limiting this segment (how specific would you get in filtering)?

any/all advice would be helpful. Cheers.