Here's my position.
I understand the philosophy that "the more followers you have, the more you will sell." But I'm leaning toward TARGETED traffic...for this reason. If I'm using Twitter to help promote my business, I want to talk to people who share the same niche and interests that I do.
That's because these are the people who are more likely to click through to my website and purchase my product. And they are also people with whom I can identify and share interests with.
And then there's the other side of the coin....
Which one would you choose? Also, would you refuse to follow or block someone who's following you and settle for fewer followers just because they don't share the same interests?